Compound guides
What the evidence actually shows
One guide per compound. Regulatory status, what the trials found, what happens when you come off it, and the myths, with a hard ceiling on what we will claim set by the evidence tier.
These are ordered by search demand, not by how interesting we find them. The first three account for the overwhelming majority of interest in this category; the rest are the research peptides people ask about most.
The set
| Compound | Class | Tier | Status |
|---|---|---|---|
| Semaglutide | GLP-1 receptor agonist | Tier A | Approved |
| Tirzepatide | Dual GIP and GLP-1 receptor agonist | Tier A | Approved |
| Retatrutide | Triple GIP, GLP-1 and glucagon receptor agonist | Tier B | Not approved |
| BPC-157 | Synthetic pentadecapeptide, a 15 amino acid sequence derived from a protein found in gastric juice | Tier D | Not approved |
| GHK-Cu | Copper-binding tripeptide, glycyl-L-histidyl-L-lysine complexed with copper | Tier C | Not approved |
| Tesamorelin | Growth hormone releasing hormone (GHRH) analogue | Tier A | Approved |
| TB-500 | Synthetic fragment of thymosin beta-4 | Tier D | Not approved |
| Ipamorelin | Selective growth hormone secretagogue, ghrelin receptor agonist | Tier B | Not approved |
| CJC-1295 | Growth hormone releasing hormone (GHRH) analogue | Tier C | Not approved |
| SS-31 | Mitochondria targeting tetrapeptide, cardiolipin binding | Tier A | Approved |
| PT-141 | Melanocortin receptor agonist | Tier A | Approved |
| MT-1 | Selective melanocortin 1 receptor (MC1R) agonist | Tier A | Approved |
| MT-2 | Non-selective melanocortin receptor agonist | Tier D | Not approved |
| AOD-9604 | Synthetic fragment of human growth hormone, residues 176 to 191 | Tier B | Not approved |
| Thymosin alpha-1 | 28 amino acid thymic peptide, immune modulator | Tier A | Approved |
| Semax | Synthetic heptapeptide analogue of ACTH(4-7) | Tier C | Not approved |
| Selank | Synthetic heptapeptide analogue of tuftsin | Tier C | Not approved |
| HCG | Human chorionic gonadotropin, a glycoprotein hormone | Tier A | Approved |
| MOTS-c | Mitochondrial derived peptide, encoded in mitochondrial DNA | Tier D | Not approved |
| Epitalon | Synthetic tetrapeptide, Ala-Glu-Asp-Gly | Tier C | Not approved |
| Glutathione | Endogenous tripeptide antioxidant, glutamate cysteine glycine | Tier C | Not approved |
| Cerebrolysin | Porcine brain derived peptide preparation, a mixture rather than a single peptide | Tier C | Not approved |
| Thymalin | Peptide fraction extracted from calf thymus, a mixture rather than a single peptide | Tier C | Not approved |
How to read the tier
The tier caps what we are willing to say. Tier A is an approved medicine and we will reproduce a regulator's published label. Tier B has controlled human trial data but no approval, so we report what the trials found and stop. Tier C is weak human data and the weakness appears in the same sentence as the finding. Tier D is preclinical only, and the species goes in the sentence. The full method is on the method page.
Before buying anything in this list, the document that matters is the certificate of analysis. Our guide to reading one covers the checks that apply to every compound here.
Blends
Several of these compounds are also sold combined into a single vial. None of those combinations has been tested as a combination, and most do not publish the ratio between their components, so we cover all six on one page rather than pretending each is a separate subject. See peptide blends and what is actually in the vial.
Vendor documentation reviews
We also read vendor catalogues against their own documentation. That work sits separately from the compound guides, because it is about what a seller publishes rather than what a molecule does. See our review of the Purple Peptides blends, and of the brand's branded stacks, a United States vendor we checked page by page. The priced catalogue is the buying view of the whole site: every product from both vendors, with the price and the evidence tier in one filterable list, and a region filter so you only see the vendor that can ship to you.